- The title is a play on the phrase "a life-changing experience".
- Peter's previous attempt at chopping wood sees him dressed as Jessica Rabbit from the film Who Framed Roger Rabbit.
- During their Dr. Seuss sex role play, Lois dresses up as The Cat in the Hat while Peter is Thing 2.
Previous Episode's References /// A Wife-Changing Experience's References \\\ Next Episode's References
| << Season 20 | Family Guy Season 21 | Season 22 >> | ||||||
| #01 | Oscars Guy | #08 | Get Stewie | #15 | Adoptation | |||
| #02 | Bend or Blockbuster | #09 | Carny Knowledge | #16 | The Bird Reich | |||
| #03 | A Wife-Changing Experience | #10 | The Candidate | #17 | A Bottle Episode | |||
| #04 | The Munchurian Candidate | #11 | Love Story Guy | #18 | Vat Man and Rob 'Em | |||
| #05 | Unzipped Code | #12 | Old West | #19 | From Russia With Love | |||
| #06 | Happy Holo-ween | #13 | Single White Dad | #20 | Adult Education | |||
| #07 | The Stewaway | #14 | White Meg Can't Jump | |||||