American Dad vs. Family Guy is a Flash game that originated on the official Family Guy website.
In the game, once a character is defeated, "Finish This!" flashes on the screen and each character has their own finishing move, referencing the fatalities from Mortal Kombat.
- Peter: Rambo
- Lois: Kill Bill's Bride
- Chris: Normal Outfit
- Meg: Hale Storm (X Men)
- Stewie: Robot Jox
- Brian: Pimp
- Stan: Normal Outfit
- Francine: Statue of Liberty
- Hayley: Normal Outfit (with picket sign)
- Steve: Karate Kid
- Roger: Wonder Woman
- Klaus: German WWII gear
- Ryu from Street Fighter is also a character, and is the final boss of Arcade Mode.
- Meg's transsexual self, Ron, seen in Stewie Griffin: The Untold Story can be seen in her finishing move.
- Brian, Meg, Francine, and Steve are only playable in the turbo version.