Avatar is a 2009 American epic science fiction motion capture film written and directed by James Cameron, and starring Sam Worthington, Zoe Saldana, Stephen Lang, Michelle Rodriguez, Joel David Moore, Giovanni Ribisi and Sigourney Weaver. The film is set in the mid-22nd century, when humans are mining a precious mineral called unobtanium on Pandora, a lush habitable moon of a gas giant in the Alpha Centauri star system. The expansion of the mining colony threatens the continued existence of a local tribe of Na'vi, a humanoid species indigenous to Pandora. The film's title refers to the genetically engineered Na'vi-human hybrid bodies used by a team of researchers to interact with the natives of Pandora.
In "Grumpy Old Man", The Griffins and the Pewterschmidts are shown a theater at the Oceanside Retirement Community where the film can be stopped by pressing a button on the seat so the patrons can ask questions. While watching Avatar, one of the residents stops the film to ask why Jake Sully is blue and asks if it because he's cold. Another mispronounces Sigourney Weaver's name but notes that her character is smoking but is still a handsome woman. Peter also stops the film to ask if unobtanium is difficult to obtain.
On Jess' bucket list in "Married...With Cancer" is a wish to have a sex threesome with a tree like in Avatar.