William Bradley "Brad" Pitt (born December 18, 1963) is an American actor and producer, known for his marriage to Angelina Jolie and work in films such as Thelma & Louise, A River Runs Through It, Cool World, The Ocean's series and produced The Departed and 12 Years a Slave.
The poster promoting "Stewie Kills Lois"/"Lois Kills Stewie" is a parody of the movie poster for Mr. and Mrs. Smith, starring Brad and Jolie.
Quagmire accuses his mom of being a worse parent than Jolie and Brad in "Quagmire's Mom". The pair are completely clueless while a doctor tries to explain that their parenting has completely mess up their adopted kids.
While hanging out at the Perk Place coffee shop with their friends in "Peter & Lois' Wedding", Lois reports that Brad Pitt broke up with her in a very public way.
When Chris Christie is supposed to be portrayed by actor Brad Pitt in a movie in "Fat Actor", Peter complains about the failure to hire a fat actor and get hired as a consultant. When he forces Brad to gain weight for the role and is injured, Peter ends up taking his place.