- X: Portrait of a Y is a fairly common title form. However, given Brian's travails in this episode, the story is similar to the 70s TV movies Sarah T. - Portrait of a Teenage Alcoholic and/or Dawn: Portrait of a Teenage Runaway.
- This episode introduces Stewie’s teddy bear Rupert and Tom Tucker’s upside-down-faced son, Jake Tucker.
- The opening of the show features the sitcom Eight is Enough.
- When Brian gets out of the car, Lois is singing the song "Anything Goes" from the Cole Porter musical of the same name.
- Lois flattens the Pillsbury Doughboy with a rolling pin.
- The gag of Peter on Jeopardy! originated from Seth MacFarlane's short film "Life of Larry".
- Peter misspells MacGyver's name on the envelope. Also, although later established as 31 Spooner Street in "E. Peterbus Unum", Peter's return address shows 725 Spooner Street.
Previous Episode's Notes/Trivia /// Brian: Portrait of a Dog's Notes/Trivia \\\ Next Episode's Notes/Trivia