In syndication, this is the first episode of Family Guy in which Peter and Lois don't appear, leaving Brian as the only character to appear in every single episode. This continued until "In Harmony's Way", which was the first that Brian had ever not appeared in.
This is the first episode without any female characters.
This episode is a complete break from the traditional Family Guy formula as there are no cutaway gags or music used.
Peter is never mentioned once the whole time Brian and Stewie are in the vault, but they do mention Lois, Chris and Meg.
Brian's bottle of liquor in the safe deposit box appears to be Glenfiddich 12-year single malt scotch.
Stewie mentions that this would be his first time drinking liquor but this is not true since he had some in "Mind Over Murder" and "Stewie B. Goode". However, the first was rubbed in his mouth and the second was committed by a version of Stewie that was killed by this Stewie.
Brian eats a coconut mint Jenny Craig bar and mentions that he’s eaten a grape Chris dropped at breakfast, both of which are toxic to dogs.
Brian says that Stewie wouldn't know how to use a gun, when on numerous occasions he has been seen using lasers as well as regular guns.