C-3PO is a character from the Star Wars universe, who appears in both the original and prequel trilogies, portrayed by Anthony Daniels.
He first appears at the end of "Blind Ambition" for Peter Griffin's medal-awarding ceremony which parodied A New Hope. For Family Guy's parodies of the originals, Blue Harvest, Something, Something, Something, Dark Side, and It's A Trap!, Threepio is played by Glenn Quagmire, and acquires many of his mannerisms.