Peter Griffin goes to the restaurant set up a birthday party for Stewie in "Chitty Chitty Death Bang", but cancels the reservation when he doesn't like the service. He then tells Lois that Cheesie Charlie's was an evil torture building.
Chris' favorite game is a machine where the player puts in a dollar and wins four quarters every time. Other games include Virtual Stuck Behind a Slow Moving Bus, and games in the bathroom where Chris won a "balloon", which was actually a condom.
The restaurant also appears in the Family Guy Video Game! as the main setting for Level 10 with Peter as the playable character.
The restaurant was frequently in The Cleveland Show, although there it was called "Cheese E. Charlie's".