Coca-Cola is a carbonated soft drink sold throughout the world. It is produced by The Coca-Cola Company of Atlanta, Georgia, and is often referred to simply as Coke.
Stewie in parade balloon form appeared in a commercial for Coca-Cola that aired during Super Bowl XLII. During the course of the commercial, the Stewie balloon and the Underdog balloon fight over a floating bottle of Coke. During the course of the battle the bottle floats away from them and into the waiting arms of a Charlie Brown balloon.
The Coca-Cola advertisement featuring Mean Joe Greene is parodied again in "Road to Germany". This time, he tosses uranium to Stewie. Ironically, the advertisement first aired 40 years after the German invasion of Poland, which was the date that Brian and Stewie first landed via their time machine.
In "Spies Reminiscent of Us", Peter compares Cleveland's bathroom being the greatest discovery since fat women discovered Diet Coke, which opens up a cutaway gag showing a fat woman expressing joy over the fact that she can eat anything as long as she drinks a Diet Coke with it.
In the final scenes of "Brian's Play", several bilboard advertisements can be seen featuring stylized versions of an Apple iPhone, a Coca-Cola bottle, and the Tesla Model S in Times Square as the camera pans down.
While explaining that the network prefers fake names for products in "You Can't Handle the Booth!", Coke is referred to as 'Kuca-Cola.'