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Coca-Cola is a carbonated soft drink sold throughout the world. It is produced by The Coca-Cola Company of Atlanta, Georgia, and is often referred to simply as Coke.

Stewie in parade balloon form appeared in a commercial for Coca-Cola that aired during Super Bowl XLII. In the commercial, the Stewie balloon and the Underdog balloon fight over a balloon bottle of Coke. During the course of the battle the bottle floats away from them and into the waiting arms of a Charlie Brown balloon.[1]

In "Peter, Peter, Caviar Eater", the 1970s Joe Greene Coca-Cola commercial is parodied when Peter regrets dropping Greene's uniform, which he would've sold for a lot of money.

In "Don't Make Me Over", when Lois remarks that Meg might have a coke problem, Peter misinterprets the drug as the branded soda.

In "Padre de Familia", within regards to the possibility of Fouad being an illegal immigrant, Peter lists several companies that don't profit from non-American labor, one of which is Coca-Cola.

The Coca-Cola advertisement featuring Mean Joe Greene is parodied again in "Road to Germany". This time, he tosses uranium to Stewie. Ironically, the advertisement first aired 40 years after the German invasion of Poland, which was the date that Brian and Stewie first landed via their time machine.

In "Not All Dogs Go To Heaven", Stewie takes the entire cast of Star Trek to McDonald's and gets one of them a Diet Coke.

In "Spies Reminiscent of Us", Peter compares Cleveland's bathroom being the greatest discovery since fat women discovered Diet Coke, which opens up a cutaway gag showing a fat woman expressing joy over the fact that she can eat anything as long as she drinks a Diet Coke with it.

In the final scenes of "Brian's Play", several billboard advertisements can be seen featuring stylized versions of an Apple iPhone, a Coca-Cola bottle, and the Tesla Model S in Times Square as the camera pans down.

In a flashback set in 1986 in "A Fistful of Meg", Quagmire explains that Tracey derided his choice of RC Cola over both Coke and Pepsi.

In "Peter, Chris, & Brian", Peter suggests that he and Chris go get $18 Cokes at the zoo restaurant.

In "Trump Guy", Donald Trump has a button on his desk that summons a butler to bring him a Diet Coke.

While explaining that the network prefers fake names for products in "You Can't Handle the Booth!", Coke is referred to as 'Kuca-Cola.'

Joe inherits several reproduction Coca-Cola signs in "Boy's Best Friend".

In "The Fatman Always Rings Twice", Mac's office is in the Cocaine Cola building, a nod to cocaine being an ingredient in the original formula for Coca-Cola.[2]

The flea market regionals in "A 'Stache from the Past" are presented by warm Coke

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