Lois turns on the hospital TV to reveal The Simpsons playing. This results in Peter having a hallucination over him and Homer going in and out of the bush, with Homer declaring it a meme when he does so, but Peter claiming it has the opposite effect when he does it. This is a spoof of the scene in The Simpsons episode "Homer Loves Flanders" where Homer sinks into a bush, a gif which is known to be an internet meme.
Two events that did not occur previously are Peter being eaten at a zoo and running into a tunnel painted by the Road Runner. Brian was nearly eaten by a lion in "Turkey Guys" as well as Peter having his face ripped off by a chimpanzee in the same episode.
Cleveland read three books about baseball player Johnny Bench. Johnny appeared in two episodes of The Cleveland Show as Cleveland's idol.
Lois hopes for an airport gate reunion; Brian points out that post-9/11 security has made such meetings difficult.
As the family paint the walls during the shuttle explosion, it's not clear if this refers to the 1986 or 2003 explosion.