- Jacqueline Hinton, who provided an early image of the script for this episode, was scheduled to provide a guest voice. She did not appear in the list of credits for this episode.
- In addition to Van Halen's "Panama", Ernie the Giant Chicken taunts Peter with Stephen Bishop's "On And On".
- Brenda Quagmire, Ross Fishman, and Mrs. Wilson appear in Peter's hallucination of deceased characters, despite not having been shown as deceased.
- Lois turns on the hospital TV to reveal The Simpsons playing. This results in Peter having a hallucination over him and Homer going in and out of the bush, with Homer declaring it a meme when he does so, but Peter claiming it has the opposite effect when he does it. This is a spoof of the scene in The Simpsons episode "Homer Loves Flanders" where Homer sinks into a bush, a gif which is known to be an internet meme.
- Call backs to past episodes include:
- Peter struggling to lift a bullfrog out a window in "Long John Peter".
- Peter claiming that The Godfather "insists upon itself" in "Untitled Griffin Family History".
- Peter's comments about Joaquin Phoenix in "Three Kings".
- The Petercopter.
- Two events that did not occur previously are Peter being eaten at a zoo and running into a tunnel painted by the Road Runner. Brian was nearly eaten by a lion in "Turkey Guys" as well as Peter having his face ripped off by a chimpanzee in the same episode.
- Cleveland read three books about baseball player Johnny Bench. Johnny appeared in two episodes of The Cleveland Show as Cleveland's idol.[1]
- Lois hopes for an airport gate reunion; Brian points out that post-9/11 security has made such meetings difficult.[2]
- As the family paint the walls during the shuttle explosion, it's not clear if this refers to the 1986 or 2003 explosion.
- This is the second time where Peter falls into a coma. The first was "Are You There God? It's Me, Peter".
- Peter says he's never read any books, but reads three stories each in "Three Kings" and "High School English".
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<< Season 17 | Family Guy Season 18 | Season 19 >> | ||||||
#01 | Yacht Rocky | #08 | Shanksgiving | #15 | Baby Stewie | |||
#02 | Bri-Da | #09 | Christmas is Coming | #16 | Start Me Up | |||
#03 | Absolutely Babulous | #10 | Connie's Celica | #17 | Coma Guy | |||
#04 | Disney's The Reboot | #11 | Short Cuts | #18 | Better Off Meg | |||
#05 | Cat Fight | #12 | Undergrounded | #19 | Holly Bibble | |||
#06 | Peter & Lois' Wedding | #13 | Rich Old Stewie | #20 | Movin’ In (Principal Shepherd’s Song) | |||
#07 | Heart Burn | #14 | The Movement |