Cooper Manning (born March 1974) was once an All-State High School wide receiver, and he was considered a hot prospect for the University of Mississippi. After extensive testing, he was diagnosed with spinal stenosis, a narrowing of the spinal canal, which brought his playing days to an end

Cooper Manning appears in "Save the Clam" when Meg uses the example of the Mannings as siblings that stick together. When their father Archie Manning congratulates the others on good football performances, Peyton Manning notes that Cooper was pre-approved for a credit card.

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