Eliza Pinchley is the daughter of English conman Nigel Pinchley. In "One if by Clam, Two if by Sea", Stewie tried to civilize her. His efforts eventually met with brief success, but she soon reverted to her Cockney self by wetting herself in public. Unfortunately, after her father was hanged for insurance fraud in Britain, she was sent to live in an orphanage. Blaming Lois for her ordeal, she writes a letter to Stewie saying that she will make it her life's effort to make sure that his mother suffers a vengeful and horrible death.
Eliza is voiced by Tara Strong while her singing voice is provided by Michelle Horn.