- This was the first episode to feature Mayor Adam West. This also introduces some of Meg's friends, including Beth.
- This is the first episode to mention Stewie's ambiguous sexuality.
- This is the first time that Quagmire uses his "giggity" catchphrase.
- Stewie dives into the lobster tank at Lobster Shanty.
- The story of the founding of Quahog mirrors the founding of “neighboring” Providence, Rhode Island. Providence-founder Roger Williams was exiled for speaking his mind and sought the assistance of Native Americans. Quahog founder Miles "Chatterbox" Musket is exiled for speaking non-stop and befriends not native people but a magical, talking clam.
- Meg is embarrassed by Peter acting as the Legendary Clam, comparing it to having Ronald McDonald as a father.
- Bonnie compares Joe to the character Larry from the sitcom Three's Company.
- Trying to get the cameras on him, Peter acts out a Wayland and Madame routine featuring a ventriloquism dummy. He mentions a song, “The Rainbow Connection,” sung by Kermit the Frog in The Muppet Movie.
- The replacement cast of the Griffins is Tom Arnold as Peter, Fran Drescher as Lois, Philip Seymour Hoffman as Chris, and Mary-Kate and Ashley Olsen as Stewie and Brian.
- Once the family has been completely replaced, they re-enact a scene from “Death Has a Shadow” in which a hung-over Peter lies on the kitchen table. The flashback of Peter at Church drinking communion wine appears in the DVD release of that episode too.
- Chris chastises Meg for “breaking the fourth wall.”
- When Chris is staring at Beth after Peter and Lois are done having sex, his hair is green, but no one else's hair has changed color.
- Syndicated reruns of this episode cut the part where Meg is at Quagmire’s house and walks in on him having sex with a woman on the kitchen counter and Meg runs out of the house.
Previous Episode's Notes/Trivia /// Fifteen Minutes of Shame's Notes/Trivia \\\ Next Episode's Notes/Trivia