- This episode pokes fun at the anti-vaccination movement and the disproven link between vaccines and Autism.
- This is David A. Goodman's first credited episode since 2012.
- Official closed captioning lists the name of the bat as "Bat Damon." The Family Guy Facebook page gives the name as "Batt Damon."
- Peter and Lois heed the advice of "Doctor" Jenny McCarthy. She is an actress and co-host of ABC's The View, and is noted for being one of the most vocal proponents of the anti-vaccination movement.[1]
- Meg brings up a callback to Peter being born in Mexico in "Padre de Familia", but Peter cuts her off claiming that no one remembers that.
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