Clippy is the default Office Assistant from Microsoft Office for Windows versions 97 to 2003. It is a silver paperclip who gives people reminders whoever needs help. It is included in all programs from Office, except FrontPage.
In "Lois Kills Stewie", Stewie Griffin is interrupted by Clippy when he tries to take over the entire energy grid. After it offers to help, Stewie tells Clippy to go away and that no one likes it.