In "Peter Griffin: Husband, Father...Brother?", Peter takes Chris to the Quahog Public Library to teach him about their family's history. There, they discover the history of Nate Griffin, a slave ancestor of the Griffins.
Quagmire tries to make small talk with Sharon the librarian in "The Old Man and the Big 'C'".
In "Turban Cowboy", the librarian happily counts down the seconds until books can be considered late when Peter crashes through the ceiling while skydiving with books in hand, claiming that they had "wieners" already drawn in them.
Peter and Quagmire perform their first public singing gig at the library during open mic in "In Harmony's Way".
Peter's taking up a challenge to drink from a fire hydrant results in the library being flooded in "Underage Peter".
Peter tries to teach Tom Tucker how to be young by making a skateboard video at the library in "The New Adventures of Old Tom".
When Peter is tipped off by Bill Maher that Family Guy will never win an Emmy in "Emmy-Winning Episode", he goes to the Quahog Library to research the matter. The building, despite the shortened name, has design elements from the earliest library.
Joanna works at the library in "Short Cuts" and gets along well with Stewie, whom she finds reading books by George Townsend in an effort to find out more information about Brian's old friend.
After embarrassing her by claiming to have never read a book in "Coma Guy", Lois orders Peter to read Orwell's 1984. When he goes to the library to pick it up, Joanna gives him Van Halen's CD of 1984 by mistake.
When attempting to frame Wild West for the vandalism of the library in "Wild Wild West" as he runs against the librarian, here renamed from Joanna to Elle Hitler, Peter accidentally sets the library on fire. With Elle caught between the flames and a crumbling ledge, she is saved by West, who makes good on a boast that he could levitate.