The Vegas Star Hotel is a dive that an unlucky Brian and Stewie stay at when they arrive to find their room at the Bellagio is gone during their trip to Las Vegas to see Celine Dion on "Roads to Vegas".
After losing money they got from a loan shark in an attempt to recoup their losses, Brian and Stewie decide to kill themselves rather than risk the family. But as they prepare to jump off of a balcony at the hotel, Stewie backs out, leaving Brian to fall to his death.