George Timothy Clooney (born May 6, 1961) is an American actor, director, producer, screenwriter, activist, businessman, and philanthropist, known for his work in Ocean's Eleven, Gravity, Up in the Air and ER.
In "North by North Quahog", Lois fantasies on having sex with George Clooney.
Stryker Foxx introduces Peter to George Clooney from circa 1997 at a loft party in "Foxx in the Men House". George tells about being a practical joker and hitting Nora Dunn in the head with an apple. Peter considers him a dick for striking a lady.
Peter believes Brad Pitt to be George Clooney's boyfriend in "Fat Actor".