Helen is Steve's wife who first appeared in "Brian Goes Back to College". She also suffers from motor neurone disease. They seem to fight a lot and sometimes don't like each other. They try to have sexual relations, but cannot. She also appeared with Steve in "It Takes a Village Idiot, and I Married One", singing "She'll Be Coming 'Round the Mountain".
She is voiced by Kathy (speech) MacOSX Leopard.