Saint Susan Saint James Catholic Church is where the Griffins attend Sunday services in "Stewie's First Word", marking a departure from their previous Protestant services.
In the episode, Stewie, irritated by poor Wi-Fi and a lack of chewy Chips Ahoy cookies due to Lent, screams an expletive that the entire church hears. Peter tries to use it as an excuse to leave the services early to go to breakfast.
The church hosts the pinewood derby in "Boy's Best Friend", but the cub scouts have to clear out before a meeting of child molesters can begin.
The church is renamed to Holy Christ Church in "Mister Act" where Peter becomes an altar boy after injuring his testicles on an exercise bike that he got for Lois for Vanentine's Day.