- Family Guy was pulled from the schedule after this episode aired due to low ratings and returned in March to finish airing the second season.
- The sign outside of the Quahog Mariners Banquet Hall reads Now Free of that Urine Smell.
- The scene where Peter's at church was also in the original pilot episode.
- Patrick Warburton, who voices Joe Swanson on the show, appears in this episode, voicing Superman whom he also voiced on a commercial for American Express with Jerry Seinfeld.[1]
- Mirroring the end of The Wizard of Oz, Peter gives encouraging talks to the Scarecrow and Tin Woodman, but instead of the Cowardly Lion, he compliments out-of-the-spotlight actress Kristy McNichol.
- A commercial parodies the Got milk? ad campaign.
- This episode marks the first appearance of Vern, the Vaudeville Guy; his piano-playing partner, Johnny, does not appear until "Blind Ambition".
- "Holy Crap" was also the title of an episode of That '70s Show, starring Mila Kunis, that aired on Fox on May 1, 2000. Kunis, however, would not become Meg's voice until the next season.
- When imagining himself in Hell, Peter meets Adolf Hitler, Al Capone, John Wilkes Booth, and Superman, who killed a hooker for making a joke about his premature ejaculation being "faster than a speeding bullet."
- The license plate of the Popemobile reads ZL PA PA and IL PA PA. "Il papa" means “the Pope” in Italian.
- After Brian mentions the Old Testament story in which "God told Abraham to kill Isaac," a cutaway shows President Abraham Lincoln shooting bartender Isaac from The Love Boat.
- Peter imagines his father-son business with himself as Lamont Sanford and his father as Fred G. Sanford of Sanford and Son.
- Peter says that baseball worked as a means of male bonding that worked for Rosie O'Donnell and his dad in A League of Their Own, a 1992 film depicting the founding of the All-American Girls Professional Baseball League.
- The Pope comments that he doesn't think that he is in Boston, and Peter supposedly points out Harvard, but instead points to a barn. When the Pope says "That's just a barn," Peter replies "Ohh, someone went to Yale!", a nod to the fierce rivalry between Yale and Harvard.
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