- On the TV show The Brady Bunch, Cindy asks if Bobby is really a doctor, referencing the old joke of children taking off their clothes to "play doctor".
- The lyrics to the unofficial Major League Baseball anthem "Take Me Out to the Ball Game" make their way into Brian and Peter's conversation.
- The back of the jacket of one of the Pope's road managers reads "Pope-a-Palooza," a reference to the Alternative rock festival Lollapalooza.
- Peter drives the Pope past the chain gang from the film Cool Hand Luke.
- The sequence in which Peter exclaims "To the Popemobile!" parodies sequences in which Batman and Robin rush to the Batmobile in the 1960s Batman television series, which starred Family Guy cast member Adam West.
- The escape pod refers to the similar pod used in Star Wars.
- When Francis asks Peter which is his favorite book of the bible, he responds with, "the one where Jesus swallows the puzzle piece and the man in the big yellow hat has to take him to the hospital." This a reference to the children's book, Curious George Goes to the Hospital by Margret and H.A. Rey.
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