Home Alone is a 1990 Christmas-comedy film written by John Hughes and directed by Chris Columbus that stars Malculay Culcin. The film did manage to get five sequels which were Home Alone 2: Lost in New York, Home Alone 3, Home Alone 4: Taking Back the House, Home Alone: The Holiday Heist and Home Sweet Home Alone.
"Baby Not On Board" is loosely based on Home Alone but in the episode Stewie gets left home alone.
In "Christmas Guy", the Griffins watch Home Alone With Competent Robbers in which the crooks are not fooled by the traps Kevin has set. When Kevin appears to brag of what else is in store for them, they simply shoot him so not to leave any witnesses.
In "Don't Be a Dickens At Christmas", Opie looks out his window where he sees "Old Man" Marley from Home Alone reuniting with his estranged family.
In "Stewie's First Word", when Lois returns from a resort, Peter notes that everyone is happy to have her back, but retracts part of it when he knows that Buzz from Home Alone is coming. Buzz spoofs his line from the first film noting that is pretty cool she's back. Just as Peter's willing to acknowledge that Buzz may not be a bad guy after all, he finishes with only white immigrants should be allowed in the country.