Hot Ones is an American YouTube talk show, created by Sean Evans and Chris Schonberger, hosted by Evans and produced by First We Feast and Complex Media. Its basic premise involves celebrities being interviewed by Evans over a platter of increasingly spicy chicken wings.
To celebrate Family Guy's 25th anniversary, Peter appears as a guest star on Hot Ones. Stewie is also mentioned and makes a cameo at the end. Despite spending the whole segment tasting various hot sauces and building himself up, at the end, Peter consumes a whole bottle of hot sauce, giving himself extreme diarrhea.