- This is Arif Zahir's introduction as Cleveland Brown. However, Mike Henry still credited as Cleveland's voice in carry-over episodes from the previous season, although Cleveland has no lines in "Rock Hard" or "Must Love Dogs".
- After dropping Stewie off at preschool, Lois considers herself 'on break' until 3:30pm.
- Doug wears underwear featuring Elsa from Disney's Frozen.
- Dr. Hartman's eye exam utilizes a Far Side comic book.
- Dr. Hartman compares LASIK to the veganism of elective surgeries.
- Dr. Hartman imitates Casey Kasem while insulting Thom Yorke.
- Peter inflates himself with helium in order to pursue a lost balloon.
- Peter does a call back to "Blind Ambition" when he notes that he was once blind. He also notes that they can insult the blind with impunity because they can't see the show.
- Herbert has an interest in Doug, but Chris notes that it won't last as he gets older. He also suggests that he's the only one that's reached puberty that Herbert has an interest in.
- Lois confuses Meg's Youtube for Circuit City, a defunct electronics store.
- Peter takes an orangutan to a Bananarama concert, mistaking it for something involving actual bananas. While there, the song "Venus" can be heard.
- In Doug's house, the clock on the mantle reads 10:10, but the grandfather clock shows 2:02.
- Doug does an excellent impression of Sterling Archer, courtesy of guest voice H. Jon Benjamin. Doug is voiced by Chris Parnell who stars on Archer with Benjamin.
- Doug compares his new relationship with Stewie to that of George and Kellyanne Conway.
- Helen Disingenuous and her show are comparable to Ellen DeGeneres.
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| << Season 19 | Family Guy Season 20 | Season 21 >> | ||||||
| #01 | LASIK Instinct | #08 | The Birthday Bootlegger | #15 | Hard Boiled Meg | |||
| #02 | Rock Hard | #09 | The Fatman Always Rings Twice | #16 | Prescription Heroine | |||
| #03 | Must Love Dogs | #10 | Christmas Crime | #17 | All About Alana | |||
| #04 | 80's Guy | #11 | Mister Act | #18 | Girlfriend, Eh? | |||
| #05 | Brief Encounter | #12 | The Lois Quagmire | #19 | First Blood | |||
| #06 | Cootie & the Blowhard | #13 | Lawyer Guy | #20 | The Jersey Bore | |||
| #07 | Peterschmidt Manor | #14 | HBO-No | |||||