Stefani Joanne Angelina Germanotta (born March 28, 1986), better known by her stage name Lady Gaga, is an American pop singer-songwriter. Gaga came to prominence following the release of her debut studio album The Fame (2008), which was a critical and commercial success and achieved international popularity with the singles "Just Dance" and "Poker Face". The album reached number one on the record charts of six countries, topped the Billboard Dance/Electronic Albums chart while simultaneously peaking at number two on the Billboard 200 chart in the United States and accomplished positions within the top ten worldwide.

She was mentioned in "The Hand That Rocks the Wheelchair" when Joe asked Meg about the meaning of "Lady Gaga" as Joe wonders if "Lady Gaga" may be a douche.

In "Seahorse Seashell Party", Stewie tries to talk Brian down from an acid trip from eating 'shrooms, reminding him that he got through more difficult things like seeing Lady Gaga naked.

Peter sets up a cutaway in "The 2000-Year-Old Virgin" in which he instructs a homely person intended to be Lady Gaga to move around fast to keep people from getting a good look at them during the act.

Frank Sinatra, Jr. speculates that he may be doing a duet with Lady Gaga in "Bookie of the Year", referring to her as "Lady Goo-ga."

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