Las Vegas is the most populous city in the U.S. state of Nevada and the county seat of Clark County. Las Vegas is an internationally renowned major resort city known primarily for gambling, shopping, and fine dining and is the leading financial and cultural center for Southern Nevada.
Peter lands on the Eiffel Tower at the Paris Las Vegas resort while skydiving in "Turban Cowboy", becoming impaled on its spire while being insulted by those below.
After Stewie's new teleportation device malfunctions, he believes it failed to work. But instead, it created a duplicate set of Brian and Stewie. While the prime pair fly to Las Vegas, both sets each see a road trip differently in "Roads to Vegas".
An extended cutaway gag in "Peter, Chris, & Brian" features Peter losing at Pai Gow poker in Las Vegas, then being forced to endure a final day penniless and a miserable flight home.
Hijackers attempt to force Quagmire to crash his plane into a large hotel in Las Vegas in "Passenger Fatty-Seven".