Lost in Space is a science fiction series created and produced by Irwin Allen, produced by 20th Century Fox Television, and broadcast on CBS. The show ran for three seasons, with 83 episodes airing between 1965 and March 6, 1968. A film adaption was created in 1998.
Peter Griffin sees Gilligan from Gilligan's Island and the Robot from Lost in Space in a dream induced by the lack of television in "I Never Met the Dead Man".
A cutaway in "Fore Father" parodies the series, specifically the ways in which the father and leader of the expedition send his children off with strange characters on dangerous missions.
While Brian and Stewie were looking for Muriel Goldman in the extended cut of "And Then There Were Fewer", Brian hums the theme song for Lost in Space which Stewie correctly guesses.
In "It's A Trap!", the order to "Fire at will!" results in Will Robinson's destruction, to Robot and Dr. Smith's horror.