Lucille Désirée Ball (August 6, 1911 – April 26, 1989) was an American actress, comedian, model, and film studio executive, starring in numerous sitcoms such as I Love Lucy, The Lucy–Desi Comedy Hour, The Lucy Show, Here's Lucy, and Life with Lucy.
Herbert dreams of life with Chris as they watch I Love Lucy in "The Courtship of Stewie's Father".
Peter and Quagmire working the pill line in "Burning Down the Bayit" is a parody of the I Love Lucy episode "Job Switching" in which Lucy and Ethel Mertz work a conveyor belt of chocolates.
"Stewie Is Enceinte" is a reference to an episode of I Love Lucy titled "Lucy Is Enceinte" in which she revealed she was pregnant.
Lucy is a celebrity roaster for Sammy Davis, Jr. in a Dean Martin roast infomercial in "Roasted Guy" where she becomes the butt of a joke told by Dean.
Among the television shows featured in the background during Peter's introduction to ""Family Guy" Through the Years" is an image of I Love Lucy.
Meg visits several shopping malls with pun names in "Christmas is Coming" in search of a Santa Claus that gave her her first orgasm, including "Lucille Mall."
Kevin James blames Adam Sandler for making him gain weight to be in his movies in "The Return of the King (of Queens)", claiming he was Ethyl to his Lucy.