Luke Skywalker is the protagonist of the original Star Wars trilogy.
In "When You Wish Upon a Weinstein", he is used by Lois Griffin as an example as to why laser eye surgery is so dangerous. Luke is shown holding his lightsaber above a woman about to perform the surgery. Obi-Wan Kenobi tells him to use the Force and after much complaining Luke does so and drives a hole through the woman's eye. Luke turns to Ben, asking him whether he was content with the results.
He also appeared in "Chick Cancer" embarrassing a rebel trooper by saying it was possible to shoot a proton torpedo into a two meter hole.