Mantecore was a male white tiger that was part of magicians Siegfried & Roy's act. In 2003, Mantecore attacked Roy Horne, severely injuring him by biting him on the neck. Mantecore was spared at the insistence of Roy and died after a short illness on March 19, 2014.

In "Meg Stinks!", Stewie compares a half-feral Brian to Mantecore. A cutaway shows Mantecore stopping by Horne's hospital room, concerned about getting a test, implied to be an AIDs test.

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