Marmaduke is a newspaper comic strip drawn by Brad Anderson from 1954 to 2015. After his death in 2015, the strips are co-drawn by his son Paul Anderson, and continue to be syndicated.
When Brian becomes a pariah in "Not All Dogs Go To Heaven", Peter suggests replacing him with a 'big, pie-eating dog' like Marmaduke.
In the parody of Misery in "Three Kings", Paul Sheldon, played by Brian, reads a scrapbook of proof that Stewie Wilkes, played by Stewie Griffin, is a serial killer, followed by a Marmaduke comic.
In "Be Careful What You Fish For", Billy Finn spoils the comic strip for Peter by explaining that Marmaduke is in a tree instead of a cat.
When Billy from The Family Circus dies of measles in "Hot Shots", Brian and Lois observe Marmaduke come along to lick up the vomit.
Stewie tells Brian that Rupert used to call him names in "Dog Bites Bear", including "Marmadukie."
When Brian is severely injured when trying to prove he's part cat in "Fecal Matters", Stewie gets him a Marmaduke book on tape read by Benicio del Toro.