McDonald's Corporation, is the world's largest chain of fast-food restaurants serving burgers, fries, and shakes. McDonald's is headquartered in Oak Brook, Illinois.
In "Brian Sings and Swings", Stewie comes home two hours past his bedtime and asks Brian if he remembers him, noting that he left him at the counter with a sack of burgers.
In "Not All Dogs Go To Heaven", Stewie took the cast of Star Trek: The Next Generation there for lunch. Marina Sirtis tells Stewie that she's not a fast-food eater. Brent Spiner asks for McNuggets, while Wil Wheaton asks for a cheeseburger, a hot dog and a milkshake. Stewie then orders two McChicken sandwiches and a diet coke. He asks Michael Dorn what he wanted and Michael asks for a McDLT which was discontinued in 1990.
Mayor McCheese seeks plastic surgery in "Believe It or Not, Joe's Walking on Air". Dr. Hartman rejects his request since McCheese has a cheeseburger for a head. McCheese thanks Dr. Hartman for telling him the straight facts.
In "Cool Hand Peter", it's parodied as McDaniel's.
In "JOLO", the Griffins get excited over the return of the McRib.
A cutaway gag in "Cop and a Half-Wit", shows Orson Welles performing his The War of the Worlds broadcast outside of a McDonald's to encourage the crowd to leave, while at the same time, trying to keep the staff in place.
Peter's outfit in the Quentin Tarantino segment of "Three Directors" is a homage to Ronald McDonald.
While explaining that the network prefers fake names for products in "You Can't Handle the Booth!", the restaurant is referred to as 'McDarrell's.'
Lois tells Quagmire that they way to make middle-aged women chuckleis to refer to McDonald's as 'Mickey D's' in "Island Adventure". In the same episode, Stewie and Brian find numerous discarded McDonald's sandwich boxes on 'garbage island.'