When she reminds Lois that she didn't volunteer to be an aide for a week in "Fighting Irish", she is happy to oblige. Miss Tammy repeatedly leaves Lois in charge so she can buy cigarettes from a guy she met on Craigslist, and sit in her car so she can yell at her boyfriend on the phone.
When Stewie has trouble concentrating in class in "Pilling Them Softly", she suggests that Lois seek professional help for him. She also appears in "Papa Has A Rollin' Son" when she leads the preschoolers in playing Parachute.
Stewie has a dream about being in preschool in "A Lot Going On Upstairs".
She informs the family about a measles epidemic when they take Stewie to daycare in "Hot Shots".
When Stewie develops scoliosis in "The Dating Game", she tries to make him feel special in class.
Miss Tammy is voiced by Rachael MacFarlane.