Monica is a middle-aged woman that that Quagmire tries to pick up but is shut down in "Island Adventure". When she continues to reject his advances, he seeks out Lois for advice and convinces her to come along on their date at La Bonne Maison to text him tips. With her help, he manages to score with Monica, but when Lois asks about her later, she becomes furious with him when he has moved on to other women using her advice.
Monica is voiced by Rachael MacFarlane.