Mort Goldman is Neil Goldman's father and the widower of Muriel Goldman. He is noticeably Jewish and owns Goldman's Pharmacy. He once bowled a perfect game in a rather unorthodox way by rolling the ball extremely slowly down the lane. Mort is given to conversations about rather depressing, and often grotesque, topics. Mort doesn't mind revealing details about his customer's personal health problems, for example he once went into the details about a man with hemorrhoids, telling the man's daughter and her classroom that they were like stinking little balloons and that they stung him so bad that he had to apply the lotion in his car with a sock. Mort takes on the characteristics of Sol Rosenberg, a character of The Jerky Boys created by Johnny Brennan in the late 1980's.
In the episode Mr. Saturday Knight, he was a guest speaker at Career Day at Buddy Cianci Junior High School. He later joined the renaissance fair in an attempt to overcome his fear of swords. He tells Peter Griffin that he was stabbed in the ear by a man in a pirate suit when he was five years old, and again when he was 30. He also yelled out that he miscarried.
Lois has her photo shoot pictures developed at Mort's pharmacy in "Model Misbehavior", and then poses for a series of fliers to advertise the pharmacy. It is also shown that Mort hates the presence of Greased-up Deaf Guy in his store.
In Brian the Bachelor, to ensure that Lois could not purchase acne medication to clear up his zit, Doug, Chris, under Doug's influence, broke into Goldman's Pharmacy and destroyed all the acne medication.
He sang "The Morning After" at karaoke night in The Drunken Clam in "Don't Make Me Over".
In "Long John Peter", his pharmacy was damaged by Peter and his pirate crew, who made sure that the rack of cheap pharmacy toys was blasted.
in "Stuck Together, Torn Apart" it is revealed that Mort and Muriel watch movies to "Hotel California" and that his niece is Jennifer Love Hewitt.
In the episode "No Meals on Wheels" he is afraid of Peter's "scarejew" made in the likeness of Adolf Hitler and exclaims that Jon Stewart needs to be saved.
In "April in Quahog" Mort is flipped off by Jesus and Jesus implies he's going to hell.
In "Road to Germany", Mort's grandparents, Chaim and Sarah Goldman and other relatives are revealed to live in Warsaw, Poland meaning that Mort is at least part Polish. Because of Stewie's time machine, he was able to witness his grandparents' wedding, initially believing he was in heaven. He also interrupts the customary musical number in "Road to..." episodes before it could even start.
Mort plays a Jawa in Blue Harvest and Lando Calrissian in Something, Something, Something, Dark Side and It's A Trap!. While the character gains Goldman's mannerisms, Goldman gains Calrissian's skin color.
In "And Then There Were Fewer", Mort and Muriel are invited to James Woods's mansion, where Muriel is murdered by Diane Simmons, making Mort a widower.
In "Tiegs for Two", he attends Quagmire's class on how to pick up women.