My Name Is Earl is an American television comedy series that aired on the NBC television network from September 20, 2005, to May 14, 2009. Earl J. Hickey is a petty criminal, whose winning $100,000 lottery ticket is lost when he is hit by a car. Lying in a hospital bed, he develops a belief in the concept of karmic retribution when he hears about karma during an episode of Last Call with Carson Daly.
Stewie and Brian appear in the Season 1 DVD exclusive short of My Name Is Earl titled "Bad Karma", in which Earl's trip to the hospital causes him to watch Family Guy on TV instead of Carson Daly where he originally learned about karma. Instead, Stewie's advice influences Earl to get even with everyone who's wronged him.
In "Believe It or Not, Joe's Walking on Air" Peter asks the guys "Who would you rather start a small business with? Janet Reno, after a safari, or the fat guy from My Name is Earl." Referencing the title character's brother Randy Hickey.
Trying to remember who he is, in "Forget-Me-Not", Peter says, "I sorta think my name is Earl", which cues the theme song for the series.