Nancy Davis Reagan (born Anne Frances Robbins, July 6, 1921 – March 6, 2016) was the widow of former United States President Ronald Reagan and served as First Lady of the United States from 1981 to 1989.

Brian compares his feeling with Ellie to the relationship between Ron and Nancy Reagan in "Boy (Dog) Meets Girl (Dog)". In a cutaway, Ron extracts a promise from her to ignore the AIDs crisis while focusing ineffectively on drugs.

Nancy is voiced by Rachael MacFarlane.

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