Nancy Davis Reagan (born Anne Frances Robbins, July 6, 1921 – March 6, 2016) was the widow of former United States President Ronald Reagan and served as First Lady of the United States from 1981 to 1989.
Brian compares his feeling with Ellie to the relationship between Ron and Nancy Reagan in "Boy (Dog) Meets Girl (Dog)". In a cutaway, Ron extracts a promise from her to ignore the AIDs crisis while focusing ineffectively on drugs.
In "The Man with Two Brians", Stewie reads My Turn by Nancy Reagan during family karaoke night.
In "Cootie & the Blowhard", Stewie and other cootie victims plan to protest at Bloomingdale's while trying to get Nancy Reagan's attention, although he's not even sure if she still alive.
Nancy is voiced by Rachael MacFarlane.