Natick is a town in Middlesex County, Massachusetts, United States. Natick is located near the center of the MetroWest region of Massachusetts, with a population of 32,170 at the 2000 census. Only 15 miles west from Boston, Natick is considered part of the Greater Boston area. The center of population of Massachusetts in 2000 was located in Natick.

It is where the Twinkie factory is located, as seen in "Da Boom". The Griffin Family turned Natick into New Quahog after they discovered it.

Community content is available under CC-BY-SA unless otherwise noted.