The Noid was an advertising character for Domino's Pizza in the 1980s.
In "Deep Throats", Mayor Adam West told his intern Meg Griffin to watch out for him, because it was constantly trying to ruin his pizza's freshness. When the Noid later appeared, West killed it in a graphic fight sequence, took a bite of his pizza, and remarked that it probably should have avoided him.
The family watches The Cosby Show in "Peter's Sister", updated to show the entire cast and guest stars including the Noid doped up after Bill Cosby's sex scandal became public.
Cracked.com, which originated as Cracked magazine and featured similar humor and style to Mad magazine, took a swipe at both the Noid and Family Guy after Funko issued a Noid figure in it's "Pop!" series.