One Direction are a multi-award winning English-Irish pop boy band based in London, composed of Niall Horan, Liam Payne, Harry Styles, Louis Tomlinson, and previously, Zayn Malik.
Liam Payne and Louis Tomlinson provide their own voices when the band appears in "Run, Chris, Run" as Stewie goes camping with them, feeding them horror stories of hotels with no sparkling water in the mini bar and non-skinny jeans, sending them running for the woods. Concerned about their safety, Stewie checks with Simon Cowell to confirm they are tagged.
Brian baits Stewie into helping him blind Carter by claiming he said he couldn't cut it as a member of One Direction in "The Finer Strings". Stewie objects, noting the opening left by the departure of Zayn Malik.