Pac-Man is the main character from the arcade game developed by Namco and licensed for distribution in the United States by Midway, first released in Japan on May 22, 1980. His partner, Ms. Pac-Man, appears in several related media.
In a cutaway in "Stuck Together, Torn Apart", Peter compares his trial separation from his wife Lois to the divorce of Mr. and Ms. Pac-Man. Three of the ghosts, Blinky, Clyde, and Funky, visit Pac-Man to cheer him up afterwards. Pac-Man, who took up smoking, doesn't attempt to consume them, even after the ghosts turn vulnerable.
Brian and Stewie play the game in Stewie Griffin: The Untold Story. Brian tells Stewie to get the fruit for more points but Stewie says that he can't cause there is a ghost in the way.
Ms. Pac-Man appears in a game of "Menstrual Ms. Pac Man" at St. Elmo's Clam, chased by the ghosts, while going through her period, in "Meet the Quagmires".
Also, in "Road to the Multiverse", in one of the opening scenes, Brian can be seen playing Pac-Man with Stewie as Pac-Man and the rest of the family as the ghosts.
When Peter describes Briggs' legs being shot in "Joe's Revenge", he imitates the sound effect from the video game Pac-Man when the player touches a ghost.
Peter describes Quagmire and Sujin as a cute couple, just like Pac-Man and Ms. Pac-Man in "Candy Quahog Marshmallow!". A cutaway implies Pac-Man performing oral sex on Ms. Pac-Man, accompanied by his munching sounds.
Brian listens to "Pac Man Fever" while driving the car in "The D in Apartment 23".
In "Cutawayland", Pac-Man follows Wreck-It Ralph into the restroom and is killed by the stench.
Ms. Pac-Man accuses Pac-Man of harassment in "A Wife-Changing Experience".