Pancresta is a fictional medication for diabetes that sponsors Meg's internet show after she becomes diabetic in "Girl, Internetted".
When Meg finds internet fame as #FridgeBodMeg, aka 'Refrigerator Meg' for eating anything, companies pay her to appear in the hopes of drawing her millions of followers. But when she collapses during one such live appearance at the Cream Queen in a diabetic coma, she is rushed to the hospital. After recovery, her taste for fame drives her to continue her eating while becoming a spokesperson for Pancresta, which includes side effects such as a heroin-type high, according to a body shop mechanic after it killed his wife. Peter himself becomes hooked on Pancresta and turns into a beam of light, while encouraging Lois to do the same.
Meg's continued eating soon costs her her feet. When she is honored at school, she realizes that all of her friends have become fat because of her. As she pledges to eat healthy and try to save what's left of her health, the bleachers the students are on collapses, resulting in the death of a janitor. Dr. Hartman is able to give Meg a foot transplant from the body.