Panera Bread is an American chain store of bakery-café fast casual restaurants with over 2,000 locations.
Helen Schlotz demands that Brian drop HBO because of her Christian beliefs and dictates that she will use the money instead for posters of fetuses to display outside of Panera Bread shops in "Married...With Cancer".
When Peter plays with his Mr. Potato Head in "A 'Stache from the Past", he pretends he's a swim instructor without a pool that hangs out at Panera Bread.
Stewie notes the the afterparty for the film Christie is being held at a Panera that is still open to the regular public in "Fat Actor".