This episode retcons almost all previous events. Further examples of reconing include Peter's introduction to Quagmire and Cleveland, which took place in "Death Lives". Lois' middle name was given as 'Patrice' in "Call Girl", but during her vows to marry Tom Tucker at St. Caucasian's Cathedral, it's given as 'Commondenominator'.
Stewie and Brian have no lines in this episode.
This episode introduces a new Fuzzy Door Productions logo, where the background is blue and the company name is white.
As with this episode being a broad parody of Friends which was set in New York City, the former World Trade Center towers appear in shots purporting to be Florida and Boston. Many of Friends establishing shots featured the iconic towers and were not removed after the events of 9/11.
Peter says he will tell the story of the greatest trilogy ever, The Mighty Ducks, a call back to the Star Wars episodes.
Peter says "shallow and pedantic," a call back to "Petarded".
Tom Tucker, Elmer Hartman, Seamus and Billy Zane sing Alanis Morissette's "Ironic" when attempting to court her.
Carter sings "The Band Played On", an 1890s song rather than a 1990s song.
Peter and Quagmire found Googoogle, a search engine to find information about the Goo Goo Dolls.