The Quahog Oil Refinery is the mass producer of Quahog, Rhode Island's oil, led by Bob Grossbeard.
In the episode "It Takes a Village Idiot, and I Married One", it was revealed that the company had been dumping its waste into Lake Quahog. To do so, they bribe Mayor Adam West by supplying him with hair gel. After Lois Griffin became mayor, she stopped the oil flow. However Grossbeard offered to buy her an expensive coat, in exchange for allowing the company to resume its waste depositing in the lake.