San Francisco is the cultural, commercial, and financial center of Northern California.
Quagmire invites the guys to go along on a flight to San Francisco in "Passenger Fatty-Seven". Among the sites they visit are:
- Ghirardelli Square, a landmark public square with shops and restaurants originally home to the Ghirardelli Chocolate Company.
- Lombard Street, notable for a steep, one-block section with eight hairpin turns, claimed as "the most crooked street in the world."
- The Golden Gate Bridge
- The Headquarters of Levis Strauss
- Fishermen's Wharf where the guys ride Segways.