Sandra Annette Bullock (born July 26, 1964) is an American actress who came to fame in the 1990s, after roles in successful films such as Speed and While You Were Sleeping. She has since established her career as a well-known leading Hollywood actress, with films such as Miss Congeniality and The Blind Side, for which she on her first Academy Award.
She reprises her role from Speed for Speed 3: Glacier of Doom in "Lethal Weapons".
In "Stewie Kills Lois", she appears in the film The Lake House where her character receives an unexpected gift from Keanu Reeves's character.
In "Farmer Guy", a cutaway shows Peter owning a video store that only offers rentals of the film The Proposal. When a man comes in and asks for a copy of the film, Peter says nobody has returned their copies, so he offers the man a poster of the film that shows Bullock and Ryan Reynolds, and notes that you can pretty much just get the plot of the film from that.
Peter mentions Sandra as starting in a movie idea he comes up with in "The New Adventures of Old Tom".
Lois tries to get out of being baptized in "Cat Fight" by claiming that when she gets her hair wet, she looks like a frazzled Sandra Bullock from one of her comedies.