Sherlock Holmes is a fictional detective created by Scottish author and physician Sir Arthur Conan Doyle. A London-based "consulting detective," Holmes is notable for his astute logical reasoning, his ability to adopt almost any disguise, and his use of forensic science skills to solve difficult cases.

Sherlock Holmes appears in "Secondhand Spoke" after Chris sets up a cutaway after noting that he and Stewie work perfectly together like Sherlock Holmes and Watson.

In the cutaway, Holmes notes that red clay at the scene of the investigation came from a gay bathhouse. When Watson remarks on his knowledge, Holmes looks uncomfortable and passes it off as something gained from books and "stuff."

Stewie assumes the role of Sherlock Holmes in "V is for Mystery".

Holmes is voiced by Seth MacFarlane.

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