Spider-Man is a fictional Marvel Comics superhero created by writer and editor Stan Lee and artist and co-plotter Steve Ditko. He first appeared in Amazing Fantasy #15 in 1962.
In the second segment of Stewie Griffin: The Untold Story, "Bango Was His Name Oh", Peter distracts Lois while she's gardening, by dressing up as Spider-Man, crawling along the clothesline and singing a made up song in the rhythm of Batman's theme song. The scene eventually becomes a romantic cuddle.
In "Believe It or Not, Joe's Walking on Air", he also saves Cleveland Brown when he falls off a cliff. Peter then tells him what Spider-Man told him when he needed saving, that everybody gets one chance.
In "Back to the Woods", when Brian asks Stewie how fast he can forge an ID for Peter, Stewie says he can do it faster than Spider-Man gets laid. Spider-Man is then seen clad only in his mask and boxer shorts, sitting on the edge of his bed, apologizing to a sexually unsatisfied woman under a spiderweb about his premature ejaculation.
He appeared in "Joe's Revenge", being asked for help by Peter, but refuses and becomes offended because the latter called him "Spidey" and not Spider-Man.
Peter gets Peter Parker's crotchety boss J. Jonah Jameson pictures of Spider-Man in "The Simpsons Guy", which also include pictures of women in thong underwear.
Brian tries to pass off The Bell Jar by Sylvia Plath as being written by Spider-Man to Chris in "Peter, Chris, & Brian", but returns to find Chris with his head in the oven.
In "Three Directors", Herbert offers Chris a "Spider-Man kiss" while he is hanging episode down, referencing the 2002 film version of Spider-Man, in which the titular superhero kisses his girlfriend Mary Jane while in the same position.
Peter is searching for his Spider-Man socks before falling down the stairs in "Stewie's First Word".
In "Customer of the Week", Peter tries to start a debate about everyone's favorite Spider-Man.
Spider-Man is voiced by Mike Henry.
- There is a song called "Spiderman" that was sung by a man coincidentally named Peter Griffin, that was released in 1979.
- The quote that Spider-Man uses on Family Guy "Everybody Gets One" was adapted into the Spider-Man comics in Amazing Spider-Man #600 during 2009.